In assessing the potential for additional sensitivity of infants and children to residues of thiophanate methyl and mbc, epa considered data from developmental toxicity studies in the rat and rabbit and a 2generation reproduction study in the rat. Facts thiophanate methyl all pesticides sold or distributed in the united states must be registered by epa, based on scientific studies showing that they can be used without posing. Tm is a systemic fungicide used on a variety of tree, vine, and root crops. The most recent section 3 risk assessment performed for thiophanatemethyl was the hed. Environmental protection and toxic substances november 2004 agency 7508c r. Pesticide residues in food food and agriculture organization of the. If after using topsin m wsb as recommended, and the treatment is not effective, a tolerant or resistant strain of fungi may be present. Facts thiophanate methyl pesticide all pesticides sold or distributed in the united states must be registered by reregistration epa, based on scientific studies showing that they can be used without posing.
This inventory summarizes evaluations of pesticides that have been performed by the joint faowho meeting on pesticide residues jmpr. Thiophanate is a member of the class of thioureas that is the diethyl ester of 1,2phenylenedicarbamothioylbiscarbamic acid. Agencys revised risk assessments for thiophanatemethyl, epa has identified risk. Tm is applied on the majority of crop by postemergent broadcast. Environmental protection agency national center for environmental assessment. An analysis of current thiophanate methyl uses, their benefits, the role of alternatives, impacts to agriculture from changes in thiophanate methyl use patterns, and applicator exposure 12 introduction 12 ornamentals 12 turfgrass diseases controlled by thiophanate methyl 14 dollar spot 14 brown patch 18.
Pesticide information about thiophanate methyl uc ipm. The listing of thiophanatemethyl was based upon three studies u. Thiophanatemethyl per gallon keep out of reach of children caution see inside booklet for additional precautionary statements. Thiophanate methyl an overview sciencedirect topics.
Teratology study in rabbits with thiophanate methyl epa reg. Specimen label thiophanate methyl 85%wdg revised date. Do not use products containing thiabendazole as substitutes for thiophanate methyl 85 wdg, as they are of. The listing of thiophanate methyl was based upon three studies u. Additional acute toxicity testing with channel catfish is being required because the chemically related compounds thiophanate methyl and benomyl are highly toxic to the ictalurid catfish family. Biochemical aspects thiophanatemethyl is rapidly and almost completely absorbed 8889% after oral administration of a dose of 14 mgkg bw.
An interim assessment analysis of oncogenic dietary risk on the chemical thiophanate methyl. The amended label referred to above, submitted in connection with registration under the federal insecticide, fungicide and rodenticide act, as amended, is acceptable. Thiophanatemethyl is low in water solubility and is not expected to bind. Thiophanate methyl is a member of the class of thioureas that is the dimethyl ester of 1,2phenylenedicarbamothioylbiscarbamic acid. Us epa pesticides index to pesticide types and families. Thiophanatemethyl is a fungicide used on tree, vine, and root crops references. Incompatible with strong oxidizing acids, peroxides. Epa, based on scientific studies showing that they. Thiophanatemethyl technical epa registration number. Produces flammable gaseous hydrogen with active metals or nitrides. Nufarm thiophanatemethyl group 1 fungicide tmethyl 4. Pesticide tolerance information is updated in the code of federal regulations on a weekly basis. For crops without labeled uses of thiophanatemethyl, observe a 30day plantback restriction.
Thiophanate methyl has structural similarities to propylthiouracil, a known inducer of thyroid tumors in rats and mice. Environmental protection agency, unless otherwise indicated. This regulation establishes timelimited tolerances for residues of thiophanate methyl and its metabolite methyl 2 benzimidazoyl carbamate mbc in or on citrus and blueberry. Epas ecological risk assessment suggests that tm dose not pose a. Thiophanatemethyl tm thiophanatemethyl fungicide label. In october 2005 the us epa published a red for thiophanatemethyl and its main metabolite carbendazim. Standard for the uniform scheduling of drugs and poisons. A gradual or total loss of pest control may occur over time if these fungicides are used repeatedly in the same fields. Thiophanate methyl is incompatible with strong acids and bases, and with strong reducing agents such as hydrides. Thiophanatemethyl fungicide doityourself pest control. It was determined that the acute and chronic dietary. These indexes are current as of the date indicated on this pdf. Thiophanatemethyl tm thiophanatemethyl benzimidazole is a broadspectrum systemic fungicide that is absorbed by the roots and leaves of the treated plants. Us epa, pesticide product label, thiophanate methyl 4.
Program and regulatory information about this substance, including links to epa applicationssystems, statuesregulations, or other sources that track or regulate this substance. Pesticide registration forms these forms are in pdf format and require the. Thiophanate methyl may be applied as a dip treatment for rose budwood, nursery stock and cut flowers, or for potato pieces and peanuts as a seed treatment. Thiophanate methyl is a broadspectrum fungicide used on food and feed. Details of the supplier of the safety data sheet manufacturer address. Us epa, pesticide product label, thiophanatemethyl 50%. These indexes are current as of the date indicated in the pdf file. This iris assessment for thiophanatemethyl consists of hazard identification and doseresponse assessment data and provides support for epa risk management decisions. The fungicide methyl thiophanate widely used to control some of the most. Prenatal and postnatal sensitivity of thiophanate methyl. Index to pesticide chemical names, part 180 tolerance information, and food and feed commodities by commodity december 12, 2012.
All pesticides sold or distributed in the united states must be registered by. As long as these precautions are followed, thiophanate methyl 4. Agricultural manual of requirements and guidelines. Us epa pesticides reregistration eligibility decision red for. Thiophanate ethyl has extremely low toxicity to birds and moderate toxicity to fish and aquatic invertebrates. This fact sheet summarizes the information in the red document for reregistration case 2680, thiophanatemethyl tm and its primary metabolite carbendazim methyl 2 benzimidazole carbamate or mbc. It does not include the maximum residue levels mrls that have been recommended by jmpr. Systemic turf and ornamental fungicide for control of a broad spectrum of diseases of herbaceous, bedding, flowering and tropical foliage plants, shrubs, trees and flowers in the landscape, interiorscape, nursery and greenhouse, containerized woody shrubs and trees, and turfgrass. To ensure proper receipt by epa, your objections and hearing requests must.
Environmental protection and toxic substances november. If after using thiophanate methyl 85 wdg as directed and the treatment is not effective, a tolerant or resistant strain of fungi may be present. To avoid the development of tolerant or resist ant strains of fungi, topsin m 70wp should always be tankmixed with a fun gicide of different chemistry, andor a fungicide of different chemistry should. Manual manipulation of individual algal cells across with agar surface with a. Do not use products containing f 1 thiabendazole or other products containing thiophanate wi. Since it targets a broad spectrum of diseases and plants, it has been used widely since 1973. Thiophanatemethyl is rapidly excreted approximately 47% in urine and approximately 40% in bile within 48 hours of administration.
If you want more options, follow the instructions for category a on an epa chemicalresistance category selection chart. Read the label affixed to the container for thiophanate methyl 4. Hold eye open and rinse slowly and gently with water for 1520 minutes. For male reproductive toxicity, the supporting study was a chronic rat study nisso 1972a. Thiophanate methyl is a fungicide used on tree, vine, and root crops references.
Pesticide registration forms these forms are in pdf format and require the acrobat. If after using thiophanate methyl 85 wdg as recommended and the treatment is not effective, a tolerant or resistant strain of fungi may be present. This action is in response to epa s granting of emergency exemptions under section 18 of the federal insecticide. Based on the developmental and reproductive data on thiophanatemethyl and mbc, epa determined that an additional 3x safety factor for thiophanatemethyl and that an additional 10x safety factor for mbc for the protection of infants and children as required by fqpa should be retained. Epa announced in a 2004 federal register notice that chemicals. If you want more options, follow the instructions for category c on an epa chemicalresistance selection chart. A fungicide effective against a broad spectrum of diseases in fruit, vegetables, turf and other crops including eyespot, scab, powdery mildew and grey mould. Subchronic, chronic, and other toxicity of thiophanatemethyl. When a pesticide is eligible for reregistration, epa explains the basis for its decision in a reregistration eligibility decision red document.
This iris summary has been removed from the iris database and is available for historical reference purposes. Us epa pesticides fact sheet for thiophanatemethyl. It is used as a broadspectrum systemic fungicide for agricultural use in australia. Active ingredient frac brand name of fungicide active. No later than one 1 day after the detained bags of thiophanate methyl technical and their contents if appropriate have been relabeled with the epa accepted label. Chemical and physical properties thiophanatemethyl is the accepted common name for the fungicide dimethyl 1,2phenylenebisiminocarbonothioyl bisicarbamate.
United states prevention, pesticides october 2005 environmental protection and toxic substances agency 7508c pesticide reregistration use profile r. Specimen label thiophanatemethyl 85%wdg revised date. Carbendazim, thiophanatemethyl and benomyl have low acute toxicity to. Us epa pesticides index to pesticide chemical names, part. This iris summary has been removed from the iris database and. Thiophanate methyl is rated high in hazard because it is classified as a likely human carcinogen and some of the potential exposures to children following lawn applications exceed the epa s level of concern. For more information about the substance, you may click one of the links below to take you to the relevant section. Both this supplemental label and the full thiophanate methyl 4. Discontinue the use of thiophanate methyl 85 wdg for at least one season.
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